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IAACN Symposium Review Part III
Copyright 2007 by Jim McAfee. 

This newsletter is the conclusion
of my review of the annual meeting
of the International and American
Association of Clinical Nutritionists.
The following are not word for word
summaries of what the speakers said,
but rather some of their thoughts
and my own observations on these
topics, personal experiences, and
application to GNLD supplementation.

Nigel Plummer, Ph.D.
The Gut Microflora
Dr. Plummer holds a Ph.D. in Microbiology.
He lectures at the University
of Westminster and the Institute
of Optimal Nutrition in London. He
is considered a world expert on the
influence of human gastro-intestinal
and genito-urinary tract microflora
on disease and health, including antibiotic-
associated effects, IBS, IBD,
allergy and autoimmune disease.

Dr. Plummer observed that transit
time is a critical factor in maintaining
health. The transit time is the
period of time from the ingestion of
a food until it is excreted from the
body. To maintain health the transit
time must be faster than the period
of time it takes the bacteria in the
gut to double in number. A sluggish
bowel sets an individual up for a decline
in health.
The most important factor determining
transit time is the quantity
of fiber in the diet. Fiber provides the
primary stimulus for intestinal motility.

The inner lining of the intestinal
tract is coated with a protective layer
of acidophilus bacteria. Acidophilus
prevents other more harmful bacteria
from taking up residence in the
intestinal lining. Use of antibiotics
strips the gut of this protective lining.
One of the consequences of this
can be deterioration of the competence
of the immune system.

Unfortunately, many health professionals
are unaware of the damage
they do to this intestinal lining
when they prescribe antibiotics.
They are also unaware of the importance
or re-establishing a healthy
acidophilus population as rapidly as
possible after use of antibiotics.
This subject is very current in
my mind as I recently had a wisdom
tooth extracted. I was instructed
to take antibiotics for five days. No
mention was made of what this
would do to the bacterial population
in the digestive tract, nor were any
instructions given to take measures
to assure that a healthy bacterial
population was restored as soon as
possible after the use of the antibiotics.
I took four capsules of Acidophilus
Complex a day along with Multi-
Fiber Blend to prevent problems.

A number of years ago a young
man named Jim forced his way with
great effort through the front door
of our office. He was doubled over
and in obvious pain. He explained
that he felt like a knife was being
turned slowly in his stomach creating
agonizing pain. The symptoms
had lasted for 8 months.
I asked Jim what had happened
8 months before. He explained that
he had suffered with a severe case
of pneumonia and had recovered
thanks to a heavy regimen of antibiotics.
He had been tortured with
digestive problems continually since
his bout with the pneumonia.

I sold Jim a bottle of GNLD Acidophilus
Complex and instructed
him to take a couple of capsules a
day. He called the next day to inform
me that the pain began to disappear
within a few hours of the time he
took the first tablets and by the sec-
ond day he was totally well.

Dr. Plummer pointed out that
beneficial microflora in the digestive
tract help the body excrete and
detoxify mercury. One study found
that the half-time for excretion of
mercury, a terribly toxic substance,
increased from 10 days to 120 days
after treatment with antibiotics.
Toxic methyl-mercury levels rise
in all tissues of those treated with
antibiotics. One study found that the
amount of methyl mercury in the
brains of rats increased from 25-45%
after treatment with antibiotics.

Dr. Plummer pointed out that a
generous flavonoid intake will prevent
bacteria in the gut from forming
nitrogen based carcinogens.
Diets low in phytonutrients may increase
the risk of cancers of the digestive
tract.

Dr. Plummer also observed that
two nutrients are essential for the
operation of every hormone receptor
in the human body. These two
nutrients are tyrosine (found in Enersine
and all protein products) and
iodine (Chelated Multi-Mineral).

Jorge Flechas
Chronic Inflammation
Dr. Flechas is a medical doctor
who also has a master’s degree
in Public Health. He was trained at
Loma Linda University.
Dr. Flechas focused his remarks
on lupus as an example of autoimmune
disorders. He said that in order
to cope with autoimmune and in-
flammatory disorders we must learn
to silence genes so they do not function
when they are doing harm. This,
he feels, is the future of medicine.
Nutritionally, the silencing of
genes is accomplished by a process
called methylation. A number of nutrients
support healthy methylation
including betaine (tri-methly-glycine),
folic acid, vitamin B12 (methlcobalamin),
and vitamin B6. These
are the ingredients in GNLD Lipotropic
Adjunct.

Dr. Joaquin Gonzales Aragon,
one of the world’s leading anti-aging
experts, became interested in GNLD
when he saw the Lipotropic Adjunct.
This was the product he was searching
for to promote healthy aging in
his patient population.
Other nutrients which promote
healthy methylation include lecithin
(phosphytidal choline is loaded with
methyl groups), selenium and zinc.
Hormones play an important role in
methylation as well, suggesting that
tre-en-en oils might play a supportive
role, in the methylation process.
Tre-en-en oils are strongest in their
support for adrenal and male sex
hormone function. These are the
hormones most important for methylation.
The adrenal hormone DHEA is
important in the methylation process.
Dr. Flechas pointed out that
some pain medications cause the
excretion of sulfur. DHEA is not water
soluble and can not carry out its
health contributing functions without
sulfur. Dr. Flechas observed that
40% of lupus patients appear to have
sulfur problems which may have
been contributed to by medications
such as acetaminophen and tylenol
which deplete sulfur. Supplements
rich in sulfur include protein, Cruciferous
Plus, and Allium Complex.
Eggs, cruciferous vegetables, garlic
and onion are foods rich in sulfur.
Dr. Flechas observed that arsenic
poisoning is a particular concern because
arsenic strips methyl groups
right off of DNA. Iodine deficiencies
are common and iodine enables the
body to rid itself of arsenic as well as
lead and aluminum.
The methylation defect in autoimmune
disease is on the X chromosome.
Women have 2 X chromosomes
while men have one X and
one Y chromosome. This explains
why autoimmune diseases occur
much more frequently in women
than they do in men when deficiencies
of the nutrients required for
healthy methylation develop.

David Brady
Autoimmune Disease and
Gut Flora
Dr. Brady is Director of the Human
Nutrition Institute at the University
of Bridgeport.
The majority of the immune
cells of the body (about 75%) are
located in close proximity to the digestive
tract where they prevent the
bacteria and bacterial toxins in the
gut from entering into the tissues.
Healthy intestinal flora are important
to prevent the development of
autoimmune disease.
Harmful microbes in the gut
have recently been associated with
the development of autoimmune
diseases through the mechanism
of molecular mimicry. Klebsiella has
been linked to ankylosing spondylitis.
Citrobacter has been associated
with rheumatoid arthritis. Yersinia
has been linked to Grave’s disease.
The presence of these organisms
can often be picked up by stool testing.
Healthy intestinal flora, particularly
acidophilus, tend to suppress
most of the bacteria associated with
molecular mimicry.
The concept of molecular mimicry
was first published in 1985. Since
that time it has become a favored
mechanism to explain autoimmune
Copyright 2007 by Jim McAfee. All rights reserved. 3
diseases. The concept suggests that
strings of amino acids in foods or
on bacteria mimic strings of amino
acids in our own tissues. When the
immune system targets bacterial
protein it also attacks proteins in
our own tissue which bear the same
structure as the infectious organism
or food protein the body interprets
as a threat.
Mimicry reactions can become
quite complex. For example, the gliadin
molecule in wheat has a protein
strand closely resembling adeonovirus
12 and a protein strand in the
gut lining. Exposure to the virus or
to gluten can result in autoimmune
attack against the gut.
Milk proteins and viral particles
can trigger autoimmune attack
against the beta cells of the pancreas
resulting in Type 1 diabetes. A
similarity of proteins in Epstein Barr
virus, grains and legumes, and joint
collagen may contribute to rheumatoid
arthritis.
Molecular mimicry is really a
case of mistaken identity. Susceptibility
to this phenomena depends
upon genetic makeup and poor dietary
habits.

Autoimmune attack is carried
out by T-Helper cells. There is a balance
of TH1 (T-Helper cells type 1)
and TH2 (T-Helper cells type 2). TH1
cells promote immune activity while
TH2 cells inhibit immune activity.
Autoimmunity is associated with an
imbalance in the ratio of these two
components of the immune system.
Lactic acid producing bacteria (acidophilus)
promote the proper balance
between TH1 and TH2.
Acidophilus Complex can be an
important supplement when all is
not well in the gut. The GNLD product
has several features that make it
unique including a nutrient source
to keep the organisms alive, a gelgard
technology to protect the organisms
from the hydrochloric acid
in the stomach, and viable or living
organisms.
Dr. Alex Vasquez
Use of Supplements to
Support Digestive Function
People often have autoimmune
responses to more than one tissue.
Thirty percent of those with autoimmune
hypothyroidism (Hashimoto’s
disease) also produce antibodies to
their own parietal cells where the
hydrochloric acid is produced.

Half of those with autoimmune hyperthyroidism
(Grave’s disease) have antibodies
to their own parietal cells.
Low hydrochloric acid production
is associated with many autoimmune
conditions. It may promote the
conditions by weakening immune
competence against bacterial invaders
and inhibiting proper digestion
of foods making them more allergy
provoking and more susceptible to
molecular mimicry.
A wide spectrum of disorders
are associated with low hydrochloric
acid production including vitiligo,
gallstones, GERD, heartburn, eczema,
acne rosacea, chronic hives, asthma,
multiple food allergies, osteoporosis,
alcoholism, candida overgrowth,
thinning of the hair in women, and
weak fingernails.
Low hydrochloric acid production
puts an individual at risk for
amino acid deficiencies, iron, calcium
and vitamin B12 deficiency, and
bacterial overgrowth.

Hydrochloric acid can be restored
either by direct supplementation, or
by supplying the nutrients essential
for production of stomach acid. The
younger the individual, the easier to
restore hydrochloric acid production
by supplementation with nutrients.
Dr. Hugh Tuckey worked with
hydrochloric acid deficiencies for
over 30 years. He found that the
most effective form of supplementation
was betaine hydrochloride, the
methyl donor form of the supplement.
Other forms were not as effective
at restoring the body’s own
production of stomach acid. GNLD
Betagest supplies this form of hydrochloric
acid along with a special
targeted delivery technology and a
slow release formulation to avoid irritating
the stomach lining.
Pancreatic enzymes have powerful
anti-tumor and anti-inflammatory
effects. Enzymes help digest a
biofilm protective barrier bacteria
erect to ward off attacks from the

Copyright 2007 by Jim McAfee. All rights reserved.

Disclaimer
This publication contains the opinions and
ideas of its author. It is intended to provide
helpful and informative material on the subjects
addressed in the publication. It is provided
with the understanding that the author
and publisher are not engaged in rendering
medical, health, or any other kind of personal
professional services in this newsletter.
The reader should consult his or her medical,
health or other competent professional before
adopting any of the suggestions in this
newsletter or drawing inferences from it.
The author and publisher specifically disclaim
all responsibility for any liability, loss, or
risk, personal or otherwise, which is incurred
as a consequence, directly or indirectly, of
use and application of any of the contents of
this newsletter.

immune system. Plant based enzymes
as used in the GNLD Enzyme
Digestive Aid have a much broader
spectrum of pH activity than animal
enzymes. Intestinal pH is often compromised
when individuals are ill.
Healthy bile flow is essential to
remove toxic chemicals, heavy metals,
and antigen/antibody complexes
from the body.
Americans are drenched with
toxic chemicals. The brains of those
with Parkinson’s are often contaminated
with dieldrin. A study of 1300
people found pesticides and herbicides
in everyone’s tissues. Levels
were highest in children and women
of childbearing age. Four of 22
samples of organic baby greens had
over 30 parts per billion of perchlorate.
The safety limit is one part per
billion. Dioxins cause insulin resistance
and diabetes.

Healthy gallbladder function
is not optional, it is mandatory for
good health and detoxification.
Healthy gallbladder function is promoted
by eating beets and ginger.
Adequate fiber intake is essential for
normal gallbladder emptying. Vitamin
C and adequate water intake
keep the bile acids fluid.

James LaValle
Sjogren’s Syndrome
Dry eyes and mouth afflict 1.4
million people. Contributing causes
include nutritional deficiencies, environmental
toxins, inflammation,
and intestinal problems including
dysbiosis and allergy.

Those with Sjogren’s disease, an
autoimmune condition that causes
dry eyes, usually have antibodies to
wheat protein. One of the eye proteins
is so similar to wheat in structure
that it has been called a mammalian
form of wheat. Wheat protein
antibodies cross react with eye protein
destroying the tear glands and
drying out the eyes. Clues that this
is taking place include dry eyes, itching
and burning eyes, a sensation of
a foreign body under the eye, tooth
decay, and allergy to wheat.

Nutrients which may benefit dry
eyes include vitamins A, C, and B6,
zinc and selenium, essential fatty
acids (especially omega-3 oils), digestive
aids, and cruciferous compounds
to help clear immune complexes
from the body. Avoidance of
gluten found in wheat, rye, barley,
and oats can be quite helpful.